Research Fellow (Single-molecule biophysics), Singapore

The Institute for Digital Molecular Analytics and Science (IDMxS) is launching a position for a Research Fellow to lead a project on how biomolecular condensates regulate enzyme function. The role involves developing new molecular probes and applying advanced single‑molecule spectroscopy to study enzyme dynamics in both condensate and dilute environments.

• Lead an independent project studying the regulation of enzyme function by biomolecular condensates.
• Design and validate novel molecular probes or synthetic condensates using genetic engineering or generative protein design.
• Apply advanced single‑molecule spectroscopy methods to measure molecular dynamics in vitro and in cell.
• Publish high‑impact findings through scientific papers and conference presentations.

• PhD in biophysics, biochemistry, molecular biology, cell biology, or a closely related field.
• Strong track record of experimentation and quantitative thinking.
• Demonstrated ability to analyze complex datasets and communicate results clearly (talks, manuscripts).
• Strong motivation, reliability, and ability to work both independently and with a team.
• Experience with single‑molecule spectroscopy techniques (e.g., smFRET, FCS).
• Expertise in protein/DNA biochemistry, including labelling strategies, expression, purification, activity assays, and reconstitution.
• Data analysis skills are advantageous, particularly experience with MATLAB, Mathematica, or similar platforms.
• Experience in live‑cell imaging is helpful but not required.
• Experience with microfluidics (device operation, rapid mixing, or reaction control) is advantageous.